Heart Imaging Genetics Knowledge Portal (Heart-KP)

Integrating knowledge and data for human heart research
Imaging Genetics Online Server
GWAS Summary Data Download
UNC-BIGS2 Lab
Brain Imaging Genetics Website
  • Heart Imaing Genetics Knowledge Portal

  • Integrating data and knowledge to study heart health and disease More website functions coming soon

Welcome to Heart-KP!

This knowledge portal serves as a platform for accelerating research into human hearts.
Construction is ongoing on this portal. We strive to cover the full spectrum of biomedical data and knowledge about heart health and disease, especially on heart imaging and genetics/genomics.
We have analyzed the genetic architecture of 82 heart imaging traits from more than 40,000 individuals in
UK Biobank
Our research results are made public through the following resources.
If you need further information or have any questions or comments, please contact Bingxin Zhao (bxzhao@upenn.edu) or Hongtu Zhu (htzhu@email.unc.edu). Reference: Heart-brain connections: phenotypic and genetic insights from 40,000 cardiac and brain magnetic resonance images (2021). Medrxiv LINK Changelog:Sep 17, 2021- Initial launch of website Oct 27, 2021- GWAS summary statistics of 82 CMR traits shared on Zenodo Nov 04, 2022 - Update of GWAS summary statistics of 82 CMR traits on Zenodo and online server

1. Heart Imaging Genetics Online Server

We build a GWAS browser using the PheWeb tool to explore GWAS results for heart imaging traits. Currently, we support GWAS results of 82 traits trained in the UKB British cohort (n~31,000), including 64 left ventricle traits, 4 left atrium traits, 4 right ventricle traits, 4 right atrium traits, 3 ascending aorta traits, and 3 descending aorta traits.

2. GWAS Summary Statistics Data Download

GWAS summary statistics for the 82 heart imaging traits can be free download from Zenodo: https://zenodo.org/record/7239166
Also, welcome to check out our Brain Imaging Genetics Knowledge Portal (BIG-KP) !!

Heart-KP website maintenance

Zirui Fan ziruifan@upenn.edu Yue Yang yyang96@unc.edu Bingxin Zhao bxzhao@upenn.edu

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